CD8A and cancer: Given the correlation between tissue levels CD8+ memory T cell, peripheral intermediate monocytes, and the tissue colocalization of the CD8+ memory T cells with the CD74+ macrophages, we can imagine a role for our myeloid population in inducing post-treatment expansion of CD8CM potentially via a mechanism involving cross-presentation of antigens released by drug-induced cancer cell death (Colbert et al., 2020).