This effect was due to inhibition of the thymus activation regulated chemokine (TARC) and macrophage-derived chemokine (MDC) in Interferon-γ (IFN-γ)/tumor necrosis factor-α (TNF-α)-stimulated HaCaT cells, which occurred by blocking activation of the NF-κB/signal transducerand activator of transcription 1 (STAT1) signaling pathway, thereby inhibiting the development of AD-like skin lesions. The gene discussed is TNF; the disease is Alzheimer disease.