The results revealed that there were various significant signaling pathways related to each signature gene, and the shared signaling pathways mainly included allograft rejection, antigen processing and presentation, apoptosis, cell adhesion molecules, B cell receptor signaling pathway, chemokine signaling pathway, and PD-L1 expression and PD-1 checkpoint pathway in cancer (Supplemental Table 3-16). Here, CD274 is linked to cancer.