Therefore, in addition to LAP TGF-beta-1 and CSF-1 that were expressed only at very low levels, we also removed IL18R1 and CXCL10 from the signature, leading to a 12-marker plasma signature associated with active TB and low cross-expression to other bacterial/viral lower respiratory infections and sarcoidosis. Here, CXCL10 is linked to sarcoidosis.