A decrease in HDAC6 protein levels has also been detected in aortic tissue of dissection patients compared to coronary artery disease patients, whereas mRNA levels of ECM proteins were found to be increased, including COL3A1 and COL1A2, matrix metalloprotease 2 (MMP2), tissue inhibitor of metalloproteinases 2 (TIMP2), periostin (POSTN) and connective tissue growth factor (CTGF). The gene discussed is CCN2; the disease is coronary artery disorder.