AGT and Aortic dissection: In a mouse model of aortic dissection induced by minipump administration of the lysyl oxidase inhibitor, β-aminopropionitrile (BAPN, 150 mg/kg/day), and the vasoconstrictor, angiotensin II (1,000 ng/kg/min), it was found that knockout of SOC3, an activator of JAK/STAT and negative regulator of Janus kinases/signal transducer, led to a decrease in aortic dissections (139).