Currently, there are no specific preventative therapeutics for arterial dissections, however, patients are often prescribed therapies such as the angiotensin II blocker, losartan, not only to manage hypertension (113, 114, 153, 228), but also because of its unique reverse-remodeling properties, which other antihypertensive agents such as angiotensin converting enzyme inhibitors lack. Here, ACE is linked to hypertensive disorder.