MPPE1 and cancer: Many recent scRNA-seq studies provide us with a deep understanding of the heterogeneity of DC states in human cancer, and a meta-analysis of such data across human lung, breast, liver, colorectal, and ovarian tumors has defined cDC1, cDC2, DC3, pDC, and cDC2/MoDC cell subsets and their transcriptional signatures (154).