In this study tumor specific overexpression of PDGF-BB in the T241 fibrosarcoma and LLC lung carcinoma cells subcutaneously inoculated into mouse models was shown to induce erythropoietin production by stromal cells, stimulating extramedullary erythropoiesis in both spleen and liver, and promoting angiogenesis and tumor growth (150). This evidence concerns the gene EPO and neoplasm.