MPPE1 and cancer: In a related study in the KPC (KrasLSL-G12Dp53LSL-R172H/+ Pdx1-CRE) mouse model of PDAC cancer a systemic decline in cDC1 cells with disease progression was also reported, however here it was not associated with a significant depletion of cDC precursors or abnormalities in cDC1 development in the bone marrow.