The expression of B7-H4 in gastric (169, 170), breast (171, 172), lung (145), prostate (173), pancreatic (174), bladder (175), colorectal (176), ovarian (177), renal (178), urothelial (179), esophageal (180), and gallbladder (181) cancers is associated with tumor size, primary tumor grade, TNM stage, low survival rate, drug resistance and a decreased number of tumor-infiltrating T cells. This evidence concerns the gene VTCN1 and neoplasm.