MAPK8 and inborn error of immunity: Our findings indicated that CDK5R1-related genes were mainly enriched in primary immunodeficiency, B cell receptor signaling pathway, Toll-like receptor signaling pathway, complement and coagulation cascades, regulation of immune response, activation of the innate immune response, lymphocyte costimulation, WNT signaling pathway, regulation of JNK cascade, cell cycle, T cell differentiation in the thymus, negative regulation of exocytosis, and axon guidance (Figure 7(e)), and these pathways were inhibited in the C2 subgroup.