GSVA revealed that the AD patients in the C1 subgroup were mainly enriched with DECRGs related to the primary immunodeficiency, B cell receptor signaling pathway, Toll-like receptor signaling pathway, complement and coagulation cascades, regulation of immune response, activation of innate immune response, lymphocyte costimulation, WNT signaling pathway, regulation of JNK cascade, cell cycle, T cell differentiation in thymus, negative regulation of exocytosis, and axon guidance. This evidence concerns the gene MAPK8 and Alzheimer disease.