Our findings indicated that CDK5R1-related genes were mainly enriched in primary immunodeficiency, B cell receptor signaling pathway, Toll-like receptor signaling pathway, complement and coagulation cascades, regulation of immune response, activation of the innate immune response, lymphocyte costimulation, WNT signaling pathway, regulation of JNK cascade, cell cycle, T cell differentiation in the thymus, negative regulation of exocytosis, and axon guidance (Figure 7(e)), and these pathways were inhibited in the C2 subgroup. Here, CDK5R1 is linked to inborn error of immunity.