The median NLR and PLR were higher in SSc patients with ILD than others [2.7 (IQR 2.5) vs. 2.5 (IQR 1.4), P = 0.038; 160.0 (IQR 97.3) vs. 139.1 (IQR 79.4), P = 0.010, respectively], and SSc patients with ILD had higher proportions of elevated ferritin, elevated KL-6, ANA positivity, and anti-Scl-70 positivity (28.1 vs. 14.2%, P = 0.011; 67.8 vs. 50.0%, P = 0.007; 86.0 vs. 69.8%, P = 0.003; 47.9 vs. 30.2%, P = 0.006, respectively), while SSc patients without ILD were more often ACA positive (33.0 vs. 19.0%, P = 0.016, respectively). This evidence concerns the gene BTG3 and interstitial lung disease.