The results showed that there was no statistical difference between the presence or absence of combined MetS and prostate volume in mPCA patients (P=0.098), while there was a significant correlation between high initial PSA levels (≥100ng/ml), high pathological Gleason score (≥8), PSA after 7 months of ADT , high tumor load and high T-stage (≥4) (P<0.05).mPCA patients with combined MetS having a more advanced tumor stage, a higher number of bone metastases, relative insensitivity to ADT treatment, a higher degree of malignancy and a poorer prognosis. The gene discussed is KLK3; the disease is neoplasm.