The presence or absence of combined MetS in patients with metastatic prostate cancer was used as the dependent variable, and factors that were statistically significant in the univariate analysis were included as independent variables (T-stage, Gleasson score, Initial PSA, Tumour load, PSA after 7 months of ADT) in a multifactorial Logistic regression analysis model with a forward stepwise method of independent variable screening.No multicollinearity among variables.The multi-factor logistic regression analysis revealed tumor load is risk factors for MetS with mPCA patients (P=0.007). This evidence concerns the gene KLK3 and metastatic prostate carcinoma.