The interaction test showed that there was no significant difference among each stratification in the association between SII and DKD, indicating that there was no significant dependence of age, gender, eGFR, ACR, BMI, hypertension, hyperlipidemia, anti-inflammation therapy, metformin use, and insulin use on this positive association (all p for the interaction > 0.05, Figure 2). This evidence concerns the gene INS and Hypertension.