IGFBP2 and esophageal cancer: Besides, the area under curve (AUC) [0.887, 95% confidence interval (95% CI): 0.799-0.975] of the combination of the IGFBP-2 level, albumin level, absolute lymphocyte count and PNI in predicting the poor prognosis of esophageal cancer patients was the largest, with the sensitivity and specificity of 94.12% and 92.47%, respectively (P<0.05).