In this study, it was found that left neck anastomosis combined with placement of feeding nutritional applicators carrying ^(125)I particles effectively controlled and relieved esophageal cancer in patients, demonstrated by the removal of tumor tissues, a markedly decreased level of serum IGFBP-2, obviously relieved symptoms such as dysphagia, and the recovered nutritional absorption. Here, IGFBP2 is linked to neoplasm.