In this study, therefore, the changes in the serum IGFBP-2 level and nutritional status in patients with esophageal cancer before and after left neck anastomosis combined with placement of feeding nutritional applicators carrying ^(125)I particles and in healthy people were compared and analyzed, so as to explore the roles of the serum IGFBP-2 level and nutritional status in the treatment of esophageal cancer with left neck anastomosis combined with placement of feeding nutritional applicators carrying ^(125)I particles. This evidence concerns the gene IGFBP2 and esophageal cancer.