Single cell RNA sequencing analysis showed that the co-suppressed signal mediated by TIM-3 or TIGIT in DLBCL seemed to be the main driving force of T cell failure.These data suggest that TIGIT, as an inhibitory receptor, may affect the tumor microenvironment of DLBCL and negatively regulate the function of T cells together with TIM3.In NHL, it has been confirmed that TIGIT is widely expressed in T cells, and most of them have high co-expression of PD-1 to stimulate the release of inhibitory cytokines (30). The gene discussed is HAVCR2; the disease is diffuse large B-cell lymphoma.