PD-1 TILs and LAG-3 TILs were correlated (r=0.204, P=0.008), TIM-3 TILs and TIGIT TILs were correlated (r=0.158,P=0.050), and TIM-3 tumor and TIGIT tumor were correlated (r=0.198, P=0.017).However, no correlation was found between the expression of the same immune checkpoint in TILs and tumor cells (Table 4). This evidence concerns the gene PDCD1 and neoplasm.