HAVCR2 and neoplasm: We speculated that the expression of TIM-3 in tumor cells also affected the tumor microenvironment of DLBCL, which was manifested as the aggravation of clinical symptoms.In addition, TIM-3 in TILs is associated with Ann-Arbor stage (Table 1), which is derived from a patient’s actual tumor invasion and is commonly used to assess the malignancy of the disease.Benjamin et al.