The TIM family includes TIM-1, TIM-3, and TIM-4, located on chromosome 5q33.2.TIM-3 inhibits tumor immunity by stopping the helper T(Th) cell immune response primarily by recognizing the ligand Galectin- 9 (9).TIM-3 expression can be detected in some solid tumors and can be used as a therapeutic target or prognostic indicator (10).In hematological tumors, TIM-3 overexpression was found in Regulatory T cell (Treg) in peripheral blood of Chronic Lymphocytic Leukemia(CLL) patients, which promoted the binding with galectin-resulting in Treg/Th17 imbalance and decreased immune function (11). Here, TIMD4 is linked to B-cell chronic lymphocytic leukemia.