BMI1 and neoplasm: Of note, the levels of Bmi-1 protein were significantly positively correlated with the degree of tumor differentiation (P = 0.035), T stage (P = 0.0023), N stage (P = 0.0221), clinical stage (P < 0.001), lymph node metastasis, and depth of invasion, but not with gender (P = 0.871), age (P = 0.523), Lauren classification (P = 0.982), or tumor size (P = 0.323) (Table 1).