Although dengue virus infection may share gastrointestinal signs and symptoms with acute pancreatitis, the differentiating factor in this case is the presence of elevated pancreatic enzymes, which do not occur in dengue fever alone, accompanied by the ultrasound abnormalities already described, which directs our diagnosis to acute pancreatitis associated with dengue virus infection, given the positivity for dengue IgM at the initial evaluation of the patient. Here, CD40LG is linked to acute pancreatitis.