OPA1 and ischemic cardiomyopathy: In support of this finding, Opa1 deficiency has been identified to correlate with I/R-mediated mitochondrial segregation (Ong et al., 2010; Chen et al., 2008) and additionally, Chen and others reported decreased Opa1 levels in human hearts samples with ischemic cardiomyopathy (Chen et al., 2008).