Hepatic cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE) system (CBS/CSE system) is an emerging therapeutic target in NAFLD for it is the system which regulates homocysteine and cysteine metabolism and it is a key role in endogenous hydrogen sulfide (H2S) biosynthesis (Sarna et al., 2015), which means in some way, the level of homocysteine and its metabolism could be related to liver damage like NAFLD, NASH and Cirrhosis. This evidence concerns the gene CBS and metabolic dysfunction-associated steatotic liver disease.