ERBB2 and breast cancer: In this study, we aimed to identify GPCR-targeting drugs for repurposing in triple-negative BC (TNBC) and drug-resistant human epidermal growth factor receptor-2-positive (HER2+) BC due to the unmet clinical need to discover novel targets and drugs (Kolbasnikov, 1987; Dai et al., 2015; Madrid-Paredes et al., 2015; de Melo Gagliato et al., 2016; Goutsouliak et al., 2020).