TGFB1 and neoplasm: The immune scores of C3 and C4 with better prognosis were much lower than those with worse prognosis, which indicated that with the significant activation of cell senescence pathway, GBM could be induced to age and tumor growth could be inhibited, just as TGF-β-induced p15INK4B expression accelerated the aging of liver cancer (Senturk et al., 2010).