Besides methylation and IDH patterns, cell senescence is also an important factor that has been demonstrated to correlate with GBM development and the response to cancer therapy (Jinno-Oue et al., 2010; Schosserer et al., 2017; Calcinotto et al., 2019; Broestl et al., 2022). The gene discussed is IDH2; the disease is glioblastoma.