PPARA and melanoma: As shown in Figure 6, we found that leukocyte transendothelial migration, primary immunodeficiency, intestinal immune network for IgA production, complement and coagulation cascades were reached in the low-risk group, while retinol metabolism, PPAR signaling pathway, pathways in cancer, melanoma, MAPK signaling pathway were enriched in the high-risk group (p < 0.05).