RGS5 (regulator of G protein signaling 5), a family of GTPase activating proteins, is extensively up-regulated in a variety of malignant cells, including non-small cell lung cancer (Huang et al., 2012), renal cell carcinoma (Furuya et al., 2004), and ovarian cancer (Wang et al., 2019), and is associated with tumor growth and poor prognosis. Here, RGS5 is linked to renal cell carcinoma.