The SAFEHEART registry with 2752 FH + patients with a mean age of 44 years upon enrollment was compared to 993 unaffected relatives showed 39 cases of any peripheral artery disease in the FH group compared to two cases in the control group, and 14 cases of peripheral artery revascularization in the FH group, compared to none in the control group (Pérez de Isla et al., 2016). Here, FH is linked to peripheral arterial disease.