LCK and neoplasm: In addition, higher expression of LCK has been confirmed in this work that it also upregulated the expression levels of CXCL9, CXCL10, and CXCL 11, which were reported to initiate a chemokine network to contribute to the generation of a “hot” (or T-cell–inflamed) tumor microenvironment (Reschke and Gajewski, 2022).