In the TME, M1-like macrophages are capable of recruiting and activating CD8+ T cells and NK cells via antigen presentation to the T-cell receptor and the secretion of tumor-derived chemokines including CXCL9, CXCL10, and CXCL11 (Hadrup et al., 2013; Susek et al., 2018). This evidence concerns the gene CXCL10 and neoplasm.