CD8A and neoplasm: Interestingly, except for being associated with CD8+ T-cell infiltration, we found that the expression level of LCK also positively correlated with M1-like macrophage infiltration in most kinds of solid tumors, indicating a universal association between LCK and M1-like macrophage infiltration in the TME, which also suggested additional functions of LCK in tumor progression except for regulating T-cell maturation.