In clinical practice, liver reserve function is often evaluated by Child-Pugh (CP) score, indocyanine green 15-min retention rate (ICG-R15), albumin-bilirubin (ALBI) score, and model for end-stage liver disease (MELD) score (Yamada et al., 2011; Hiraoka et al., 2017; Wang et al., 2018; Wang et al., 2020; Demirtas et al., 2021). The gene discussed is ALB; the disease is End Stage Liver Disease.