Here, we have identified several plausible pathogenic alterations underlying LUAD-BM and LUSC-BM that affect potentially targetable genes, including CDK12, DDR2, ERBB2, and NTRK1. NSCLC-initiating driver events, such as alterations affecting EGFR and ALK genes, are highly concordant between primary NSCLC and matched BM lesions.47 This evidence concerns the gene NTRK1 and non-small cell lung carcinoma.