The three most significantly amplified genes in BM were MLLT11 (60.8% of BM versus 54.9% of NSCLC), TP63 (47.1% versus 25.5%), and MYC (49% versus 27.5%), whereas the three most significantly deleted genes in BM were CDNK2A/B (23.5% versus 11.8%), DCC (31.4% versus 0%), and TBX3 (13.8% versus 0%). The gene discussed is MYC; the disease is non-small cell lung carcinoma.