More recently, 12 pairs of primary NSCLC and matched BM were profiled by WES, revealing several BM-associated mutations in known cancer genes, including AHNAK2, ANKRD36C, BAGE2, KMT2C, and PDE4DIP. 11In another study, WES profiling of 10 pairs of primary LUAD samples and matched BM and liver metastases revealed distinct metastatic mutational landscapes and evolutionary patterns.12 Here, KMT2C is linked to non-small cell lung carcinoma.