The expression of some mitophagy regulators such as LC3, BNIP3, beclin1, Atg7, p62, and parkin decreases with age, indicating that sarcopenia is associated with dysfunctional or deficient mitophagy (Zhao et al., 2018a; Yoo et al., 2018; Liang et al., 2020). Here, PRKN is linked to sarcopenia.