The balance between fusion and fission, which is essential for maintaining effective mitochondrial function in skeletal muscle, is often compromised with age (Romanello, 2021) due to decreases in mitochondrial fission factors (Drp1, Fis1, and Mff) and mitochondrial fusion factors (Mfn1, Mfn2, and OPA1) in people with sarcopenia (Di Liu et al., 2021). The gene discussed is OPA1; the disease is sarcopenia.