Caulerpenyne is a sesquiterpenoid-structured secondary metabolite which has some bioactivities such as antiproliferative and apoptotic activities (Cavas et al., 2006) and inhibitors of lipoxygenase (Cengiz et al., 2011) and 5-lipoxygenase (Richter et al., 2014), etc. Secondary metabolites of genus Caulerpa are responsible for complex modulation network induced in AMPK, ER Stress, mitochondrial stress, PTP1B inhibition and cell cycle stop pathways, metabolic reprogramming in cancer cells, apoptosis and cell cycle arrest in cancer metabolism (Mehra et al., 2019). Here, PRKAA1 is linked to cancer.