In addition, we screened 15 drugs targeting key genes from the DrugBank database, most of which are used to relieve pain, systemic anesthetics, inhibit signaling, inhibit cyclin-dependent kinases, inhibit multiple enzyme targets (including CDK7) and change the growth phase of treated cells, treat depression, it is used in potassium channel blockers, ameliorates multiple sclerosis (MS), and so on. This evidence concerns the gene CDK7 and major depressive disorder.