DPP4 and type 2 diabetes mellitus: A randomized controlled trial for omarigliptin, a once-weekly DPP-4 inhibitor, was performed to assess CV outcomes in 4,202 patients with T2DM and established CV disease over a median follow-up of 1.8 years.35 No significant difference was observed between omarigliptin and placebo in the occurrence of the MACE-3 primary end point (5.5% vs 5.4%; HR, 1.00; 95% CI, 0.77-1.29).