COMP and skeletal dysplasia: Disease-associated variants in COMP cause impaired cartilage development leading to skeletal abnormalities such as short stature and skeletal dysplasias (Briggs et al., 1995; Hecht et al., 1995; McKeand et al., 1996; Hecht et al., 1998; Unger and Hecht, 2001; Hecht et al., 2005; Posey and Hecht, 2008).