In addition to disrupting mitochondrial function (Borsche et al., 2020), Pink1 mutations in PD patients have also been shown to increase central nervous system vulnerability to reactive oxygen species, to dysregulate dopamine (DA) synthesis and reuptake (Gautier et al., 2008; Bus et al., 2020; Goncalves and Morais, 2021), to induce ferritin accumulation and iron toxicity in midbrain DA neurons (Hagenah et al., 2008) and to promote alpha-synuclein aggregation (LSamaranch et al., 2010; Takanashi et al., 2016; Nybo et al., 2020). The gene discussed is PINK1; the disease is Parkinson disease.