One study revealed that TP53 and RB1 mutations can be found among all types of bronchial neuroendocrine tumors (TCs, ACs, small cell, and large cell neuroendocrine carcinoma), however their prevalence increases in the more poorly differentiated small cell and large cell neuroendocrine carcinomas.89 This evidence concerns the gene RB1 and large cell neuroendocrine carcinoma.