Quantitative PCR and immunohistochemical analysis showed that LIF, LOX, MMP9, S100A4, SRPX2, and TIMP1 were expressed at high levels in glioma, whereas SLITI1 and SMOC1 were expressed at low levels, consistent with our previous results (Fig. 7; Fig. S4). The gene discussed is SMOC1; the disease is glioma.