To investigate the infection of SARS-CoV-2 VLPs requiring the protease activity of TMPRSS2, 293T-ACE2 cells were infected by atto647N-SARS-CoV-2 VLPs in a treatment of 100 mM of Camostat, a pharmacological inhibitor of TMPRSS2. This evidence concerns the gene TMPRSS2 and infection.