These coincide with our findings that pretreatment, but not co-treatment, with HDACi panobinostat enhances oHSV replication, which may be mediated by downregulation of the transcriptional levels of IFN-β- and IFN-responsive antiviral genes in glioma A172 and squamous cell carcinoma SCC9 cells. Here, IFNB1 is linked to central nervous system cancer.