Furthermore, production of IFN-β, IFN-λ1, and IP-10 was significantly increased during ADE of ZIKV infection compared to uninfected cells (10.1 vs. 1.3 pg/mL for IFN-β, 14.7 vs. 3.0 pg/mL for IFN-λ1, and 2889 vs. 19.8 pg/mL for IP-10, p < 0.001, p < 0.001, and p < 0.0001, respectively, Figure 5D). This evidence concerns the gene IFNB1 and Zika virus infectious disease.