For THP-1 cells, IL-8 production of cells infected with ZIKV + 4G2 was statistically significantly higher compared to uninfected cells (average 43.7 vs. 35.7 pg/mL, p = 0.007), while for K562 cells, a decrease in IL-8 production was found during ADE of ZIKV infection compared to uninfected cells (426.4 vs. 350.8 pg/mL, p = 0.014). Here, CXCL8 is linked to Zika virus infectious disease.