Additionally, p16, Ras association domain family 1 isoform A (RASSF1A), GSTP1, and Retinoblastoma protein-interacting zinc-finger gene 1 (RIZ1) are genes with aberrant methylation levels in HCV infections associated with hepatocellular carcinoma [64]. This evidence concerns the gene CDKN2A and hepatocellular carcinoma.