Conversely, there was a significant 2.943-fold increase in ACE2 expression and significantly altered expression of pro-inflammatory and pro-coagulation genes, including 1.306-fold for F3 and 0.548-fold for ICAM1 (p < 0.05) in patients with COVID-19 compared with healthy controls (Table 1; Figure 3A). Here, ICAM1 is linked to COVID-19.