TP53 and COVID-19: In COVID-19 samples, there were significant decreases in the following genes compared with healthy individuals: 1.127-fold for F2R, 1.097-fold for PROCR, 1.040-fold for PROC, and 0.193-fold for TP53 (p < 0.05) (<10% of PBMC expressed these genes compared with healthy controls) (Table 1; Figure 3A,B).