SH2D3C and infection: Infection induces RNA-dependent protein kinase (PKR)-mediated phosphorylation of eIF2α, cessation of host protein and viral nsP synthesis and ADP-ribosylation-dependent aggregation of translation initiation factors (eIFs) and RNA-binding proteins (RBPs) from stalled ribosomes into stress granules that are disrupted by the formation of nsP3 granules [40,41].