We show that transduction with the optimized GGHI-mB-3D vector leads to a significant increase in the Aγ/α ratio and HbF, along with a concomitant decrease in HbS in our patient cohorts, thus demonstrating an increased potential of improving, as well, the SCD phenotype in vitro compared to GGHI. This evidence concerns the gene RENBP and Schnyder corneal dystrophy.