RNASE2 and asthma: Eosinophils contain toxic granules (i.e., major basic protein (MBP), eosinophil cationic protein (ECP), eosinophil-derived neurotoxin (EDN), and eosinophil peroxidase) and efficiently produce ROS upon various stimulations, such as that effected by cytokines, and enhanced effector functions by eosinophils can cause tissue injury and airway remodelling in RV-induced asthma [114,115].