YAP1 and hepatocellular carcinoma: For example, it is reported that circ-Vav3 expression is up-regulated in chicken hepatomas infected by avian leukemia virus J-subunit, causing sponging of gga-miR-375 to eliminate the effect of the miRNA on its target gene, YAP1, increasing YAP1 expression, and inducing the epithelial-mesenchymal transition [67].