These data suggest that JCPyV localization with DRD2 could be either due to a specific interaction between DRD2 and JCPyV or due to heterodimerization between the GPCRs, DRD2 and 5-HT2R [117], that serve as a target for JCPyV during infection [117,118]. This evidence concerns the gene DRD2 and infection.