These NK cell receptors have a crucial function on T cells and act as a co-stimulatory molecule on CD8+ T cells for efficient stimulation by non-professional antigen-presenting cells and optimal activation of effector functions of CD8+T cells in tumor tissue, whereas CD161+CD8+ T cells show long-term memory, cytotoxic potential, drug efflux capacity, and are the candidate of choice for adoptive cell transfer therapy [28,29]. Here, KLRD1 is linked to neoplasm.