However, we report that MIC-B and PVR were significantly reduced in the PF of HGSOC, although grouping patients based on the dissemination of tumor cells into ASC+ and ASC- groups revealed themselves to be highly soluble MIC-B in ASC+ patients, which indicates that the dissemination of tumor cells may directly contribute to the shedding of MIC-B in PF. The gene discussed is MICB; the disease is neoplasm.