At the molecular level, HBcAg showed a multi-Toll-like receptor (multi-TLR) agonist effect, stimulating human hepatoma (HepaRG) cells (infected or not with the HBV), increasing the expression of Toll-Like Receptor 2 (TLR2), TLR3, TLR7, TLR8, and TLR9 and their signal transduction pathways: Myeloid Differentiation Factor 88 (MyD88), TRIF, IRF3, and NF-kappa B (NF-kB) [15,16]. This evidence concerns the gene TLR2 and hepatocellular carcinoma.