Although we did not detect serum Th1/Th2 type cytokine profiling, which will be helpful to reduce security concerns about ADE or VED, the immunotoxicity and systemic toxicity results in this study shows no abnormal changes, including white cells, IgG, IgM, C3, C4, CD3+, CD4+, CD8+ subtype lymphocyte, pathologic changes in immune organ, respiratory and cardiovascular response, etc. Therefore, ZF2001 may not increase the risk of ADE and VED in cynomolgus monkeys. The gene discussed is C4A; the disease is acute disseminated encephalomyelitis.