Despite this uncertainty concerning the mechanistic contribution of eosinophils to VERD, our results clearly show that proper engagement of the innate immune system upon RSV G vaccination provides essentially complete protection from viral infection and primes the host for a favorable Th1-type response while inhibiting the inflammatory Th2-type response associated with the fractalkine activity of the RSV G protein. This evidence concerns the gene CX3CL1 and viral infectious disease.