According to Allegra et al. [17], COVID-19 and carcinoma have similar markers such as the carbohydrate antigens (CA) 125 and 153, carcinoembryonic antigen (CEA), human epididymis protein 4 (HE4), C-reactive protein (CRP), and cytokeratin-19 fragment (CYFRA21-1); However, establishing whether the increase in such biomarkers is the result of COVID-19, malignancy, or both at the same time is a challenge for hospitals and clinicians (Figure 1) [14]. This evidence concerns the gene WFDC2 and COVID-19.