We also found that, in placental trophoblast BeWo, but not in MDCK/FcRn cells, ZIKV infection itself downregulated the expression of FcRn at the mRNA (Figure 4A) and protein level (Figure 4B), further underscoring the interplay between the infection and FcRn expression. The gene discussed is FCGRT; the disease is Zika virus infectious disease.