In particular, according to the “Rule-of-6” by Dickens BSL et al., the presence with SARS-CoV-2 infection within 48 h from hospital admission of CRP > 60 mg/L, ferritin > 600 μg/L, and LDH > 600 IU/L aided in early identification of COVID-19 patients at risk of deterioration to the point of ICU admission [46]. The gene discussed is CRP; the disease is COVID-19.