CD8+ T cell infiltration and retained expression of classical HLA class I strongly associates with a better prognosis in non-small cell lung carcinoma (NSCLC), cervical and ovarian carcinomas, however high expression of HLA-E abrogates this predictive score, indicating that HLA-E influences resistance to T cell immune responses [48,49]. The gene discussed is CD8A; the disease is non-small cell lung carcinoma.